Mea Hana Lactoferrin

• Hoʻokomo i ka Lactoferrin

ʻO Lactoferrin, kahi glycoprotein paʻa hao multifunctional i loaʻa mua i ka waiū mammalian a me nā wai kino like ʻole, ua loaʻa i ka nānā nui ʻana i ka noiʻi ʻepekema ma muli o kāna mau hana olaola like ʻole a me nā noi kūpono. He kiʻekiʻe ka Lactoferrin i ka colostrum a me ka waiū, i ʻike ʻia i ka waiū umauma e nā ʻepekema MONTREUIJ a me JOHANSONB i ka makahiki 1960. Ua hoʻomālamalama nā haʻawina hou i kāna mau hana, e hōʻike ana i kona komo ʻana i ka hoʻololi ʻana i ka pane ʻana o ka immune a me ka hoʻohana ʻana i nā hopena antimicrobial. He kuleana koʻikoʻi ka Lactoferrin i ka pale ʻana ma o ka hoʻopaʻa ʻana i ka hao, he mea nui ia no ka ulu ʻana o ka maʻi bacteria, a laila e kaupalena ana i ka hoʻonui ʻana o ka microbial.

ʻO Lactoferrin i hana ʻia e Yangge Biotech e kōkua i ka hoʻoponopono ʻana i ke ʻano o ka komo ʻana o ka hao i loko o ke kino mai ka ʻōpū. Me he mea lā e pale aku i nā maʻi mai nā bacteria, nā virus, a me nā fungi. Manaʻo ʻia ka lactoferrin i loko o ka waiū umauma e kōkua i ka pale ʻana i nā pēpē hānai waiū mai nā maʻi. Eia kekahi, ua hōʻike nā haʻawina he mau hana ko ka lactoferrin o ka antibacterial ākea, ka maʻi anti-viral a me ka hoʻoikaika ʻana i ka pale ʻana.

• Kūlana Kūlana o Lactoferrin

Wahi a GB1903.17—2016

• hana

ʻO Lactoferrin kahi glycoprotein hoʻopaʻa hao i ka transferrin, i hoʻopaʻa ʻia i ka waiū kanaka a me ka mammalian a me nā wai huna. Eia nō naʻe, ʻoi aku ka kiʻekiʻe o ka mea i loko o ka colostrum. Aia kekahi wahi liʻiliʻi o ka lactoferrin i loko o ka ʻili mucosal mammalian, waimaka, saliva, leukocyte particles, pancreatic wai, bile a me ka wai ʻōpū. Loaʻa iā ia ka nui o nā hana, me ka sterilization, bacteriostasis, anti-virus, immune regulation, hoʻoikaika i ka hao hao a me nā hana physiological ʻē aʻe.

1. Mea pale i ka maʻi bacteria

Ua hoʻoholo ʻia ʻo ka lactoferrin kahi mea bacteriostatic ākea ākea, hiki ke kāohi i ka bacteria Gram-negative e koi ana i ka hao, e like me coliform, Salmonella, etc. Hiki iā ia ke pale i nā hua bacteria Gram-positive. Eia nō naʻe, ʻaʻole ia e kāohi i ka bacteria me ka haʻahaʻa haʻahaʻa o ka hao, e like me ka lactic acid bacteria.

2. Mea hoʻōla viral

ʻO Pioneer Biotech ka mea hana Lactoferrin. He hana nui ia i ka pale ʻana i nā maʻi maʻi i loko o ka mea hoʻokipa, a hiki ke kāohi i ke kanaka immunodeficiency virus (HIV), cytomegalovirus, herpesvirus type 1 a me 2, hepatitis C virus (HCV), influenza virus a pēlā aku. ʻO ka lactoferrin ka lactoferrin hiki ke hui pū me nā maʻi maʻi a me nā pūnaewele hoʻokipa, i mea e pale ai i ka hui ʻana ma waena o nā maʻi maʻi a me nā mea hoʻokipa a pale i ka hopena mai ka pōʻino o ka maʻi.

3. Mea hoʻōla ʻona

ʻO nā radical free oxygen keu i loko o ke kino e hana i ka lipid peroxide, hiki ke hoʻopōʻino i nā cell a me nā ʻiʻo. He hōʻailona ia o ka ʻelemakule a me ka maʻi. Hiki i ka Lactoferrin ke hoʻopaʻa i nā ion hao a hoʻopaʻa i ka lipid oxidation a me ka hoʻololi ola ʻana o nā radical free oxygen i hana ʻia e nā ion hao. Hiki i kēia mau mea ke hōʻemi i ka pōʻino o nā radical manuahi i ka elastin i loko o ka paia arterial, i mea e pale ai a mālama i ka atherosclerosis a me ka maʻi naʻau coronary.

4. Hoʻoponopono i ka pane pale kino

Hiki i ka Lactoferrin ke hui pū me nā lymphocytes, monocytes, macrophages a me nā pūnaewele ʻē aʻe e pāʻani i nā ʻano hana like ʻole. Hiki i ka Lactoferrin ke hoʻoulu i ka pane kūlohelohe humoral, hoʻoikaika i ka hoʻonui ʻana o ka lymphocyte, hoʻoponopono i ka hana ʻana o ka iwi iwi a hoʻemi i ka mumū. I ka manawa like, hiki i ka lactoferrin ke pepehi i nā pathogens ma ka hoʻoulu ʻana i nā neutrophils e hana i nā peroxides. Hiki i ka Lactoferrin ke hoʻoulu i ka hoʻonui ʻana o nā pūnaewele mucosal intestinal a me nā cell spleen a hoʻoikaika i ka maturation o ka ʻōnaehana pale kino.

5. Kāohi i ka ulu ʻana o ke kanesa.

ʻO Lactoferrin kahi waiwai antiviral ākea ākea o nā maʻi kanaka a me nā holoholona e pili ana i ka DNA / RNA. Kū'ē i: herpes simplex virus type I a me II, cytomegalovirus, human immune deficiency virus, hepatitis C virus, hantavirus, rotavirus, poliovirus type I, human respiratory syncytial virus and murine leukemia virus.

Nānā: https://www.spandidos-publications.com/10.3892/ijo.2021.5265

6. Hoʻoponopono i ka omo ʻana o ka hao

Ma ke ʻano he mea hao hao, ʻoi aku ka maikaʻi o ka hopena absorption o ka lactoferrin ma mua o ka ferric sulfate. Hiki iā Lactoferrin ke hoʻopaʻa a lawe i ka hao. Hiki iā ia ke hoʻokuʻu i ka hao ma hope o ka hiki ʻana i ka ʻōpū o ke kanaka, hiki ke hoʻonui i ka absorption maoli a me ka bioavailability o ka hao.

7. Lactoferrin no ka mālama ʻana i ka COVID-19

I kēia mau lā, ua hoʻohana nā ʻepekema ʻAmelika i ka ʻenehana naʻauao kūlohelohe e nānā i nā kaukani o nā lāʻau lapaʻau e hiki ke hana me COVID-19, me ka lactoferrin.

Nānā: https://www.spandidos-publications.com/10.3892/etm.2020.9402

• Hoʻohana no ka lactoferrin

1. Ka meaʻai a ka pēpē

ʻo ia ka mākeke mua no nā noi lactoferrin pono. Eia nō naʻe, hoʻohana nā ʻāpana ʻē aʻe i ka meaʻai a me nā waiwai hana o kēia protein.

2. Hoʻohana nui ʻia ʻo Lactoferrin ma ke ʻano he mea hoʻohui meaʻai.

Ma ke ʻano he immunomodulator. ʻOiai ʻaʻole maopopo ʻia kāna mau hana, ʻike mākou e hoʻonui ia i ka pane ʻana mai. Ua hōʻike ʻia nā haʻawina ʻelua i mālama ʻia ma luna o nā limahana olakino e ʻai ana i ka lactoferrin i loaʻa i ka waiū bipi he hopena immunomodulatory maikaʻi (ma muli o ka ʻike mua o ka ʻōnaehana pale o ka mea manawaleʻa). Hōʻike nā hopena e hiki ke hoʻohana ʻia ka lactoferrin i loaʻa i ka waiū bipi no ka hoʻomaikaʻi ʻana i ke kūlana immune o nā maʻi a hiki ke pāʻani i ka hoʻoulu ʻana i kā lākou pane pale. ʻO nā mea hoʻohui Lactoferrin e kūʻai ʻia nei i kēia manawa aia kahi pae o ka maʻemaʻe a hiki i 96%.

3. Hoʻohana ʻia ʻo Lactoferrin i ka ʻāpana hoʻonaninani

Hiki ke loaʻa i loko o nā huahana nani he nui e like me ka make-up a me ka lauoho, ka maka a me nā mea mālama kino. No ka laʻana, ʻo kona mau waiwai antibacterial ʻo ia hoʻi he mea i ʻimi nui ʻia i nā mea hoʻomaʻemaʻe. Hoʻohana ʻia hoʻi ia i nā ʻano hairspray no ka hoʻomaʻū ʻana a me ka hoʻomaʻemaʻe ʻana i ka lauoho. Hoʻoulu pū ʻo Lactoferrin i ka metabolism o ka ʻili a he hopena anti-aging ma muli o kona mau waiwai antioxidant e hopu ana i nā radical free.

4. Hoʻohana pū ka ʻoihana hoʻomaʻemaʻe waha i ka lactoferrin

Loaʻa i ka Lactoferrin kahi pilina ikaika no ka hao, e kōkua ana iā ia e hana ma ke ʻano he mea bacteriostatic. Hoʻemi maoli ia i ka nui o nā ion ferric i loaʻa manuahi, ke keʻakeʻa nei i ka ulu ʻana o kekahi mau maʻi bacteria a me nā pilikia pili e like me ka hanu ʻino, nā caries niho a me ka tartar.

Loaʻa ka Chart

Ke ʻano o ka nānā ʻana i ka Lactoferrin

1. Ke Kumu

E hoʻohana i ka mea hana HPLC, e ʻike i ka lactoferrin ma 280nm me ke ʻano hana maʻamau.

2. E hoʻomākaukau i ka mea

2.1 Papa 1 wai.

2.2 HPLC Acetonitrile.

2.3 0.9%NaCl solution

2.4 1% trifluoroacetic acid solution: lawe 1ml trifluoroacetic acid solution, dilute me ka papa 1 wai a 100ml, e hele me 0.45μm kānana membrane.

2.5 HPLC mea hana me ka UV detector.

3. Kūlana Chromatographic

3.1 Ke kolamu chromatographic:

Alltech prosphere C4 300A(150 mmx4.6 mm),

Alltech All-guardTM Guard (7.5mm x4.6mm), a i ʻole kolamu hana like.

3.2 ʻIke i ka nalu nalu: 280nm.

3.3 Kahe kahe: 1.0ml / min.

3.4 Ka wela o ke kolamu: 35°C.

3.5 Injection Volume: 50μl.

3.6 Nā ʻāpana elution gradient.

4. Nā ʻanuʻu hoʻāʻo

E lawe i ka laʻana a me ka lactoferrin maʻamau reference 0.1g kēlā me kēia, hoʻohui ʻelua i ka wai 10ml grade 1 (a i ʻole NaCl solution), a hele i loko o ka membrane kānana 0.45μm, a laila loaʻa iā mākou ka hāpana hāpana a me ka hopena kuhikuhi. E hoʻohana i ka 50μl i kēlā me kēia e hoʻāʻo ma 280nm, a hana i ka manawa like i koe (e pili ana i 10min). ʻO ka piko nui ka piko o Lactoferrin. E helu i ka ʻāpana kiʻekiʻe ma waena o ʻelua manawa i koe. ʻO ka lakio o ka ʻāpana kiʻekiʻe nui a me nā wahi kiʻekiʻe a pau ʻo ia ka lactoferrin assay mai ka nui o ka protein.

• Hōʻike Chromatogram o Lactoferrin Reference Substance

Paʻa a me ka palekana

1. ʻO ke kūlana: Paʻa ma lalo o nā kūlana kūpono (ka mahana lumi). Loaʻa ka Pepa ʻIkepili Stability ma kāu noi.
2. palekana: Wahi a GARS (Generally Recognized as Safe) Notice of US, palekana ia no ka ʻai kanaka.

Pūʻolo Lactoferrin

He kuleana koʻikoʻi ka hoʻopili ʻana o Lactoferrin i ka mālama ʻana i ka hou o ka huahana, ka maikaʻi, a me ke ola paʻa. E noʻonoʻo i nā hiʻohiʻona paʻi ma lalo nei:

Hoʻopili ʻia i loko o ka ʻeke pepa kraft multi-layer me ka ʻeke meaʻai PE i loko o ka ʻeke, ʻupena 25kg / ʻeke. (Loaʻa nā ʻano ʻāpana ʻē aʻe ma ke noi)

Ma hea e kūʻai ai iā Lactoferrin?

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